Opioids and Their Receptors  Present and Emerging Concepts in Opioid Drug Discovery 

<br/><br/><br/>English[eng] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>opioid receptors||neurokinin-1 receptor||peptide synthesis||receptor binding studies||functional assay||writhing test||tolerance||Leu-enkephalin||beta-arrestin||mu opioid receptor||delta opioid receptor||biased signaling||DADLE||ischemia||plasma stability||morphinan||BNTX||δ opioid receptor antagonist||1H-NMR experiments||mechanism elucidation||peripheral antinociception||14-methoxycodeine-6-O-sulfate||codeine-6-O-sulfate||opioid peptides and peptidomimetics||DAMGO||DALDA||[Dmt1]DALDA||KGOP01||binding||molecular docking||structure-activity relationships||β2-amino acids||β2-Homo-amino acids||µ-opioid receptor||opioid peptides||TAPP||racemic synthesis of β2-amino acids||peripheral µ-opioid receptors||analgesia||peripheral analgesic tolerance||dysbiosis||opioid||bifunctional ligands||(−)-N-phenethylnorhydromorphone analogs||[35S]GTPgammaS assay||forskolin-induced cAMP accumulation assays||β-arrestin recruitment assays||MOR and DOR agonists||respiratory depression||bias factor||molecular modeling &amp||simulation||δ opioid receptor||NTI derivative||sulfonamide||inverse agonist||neutral antagonist||agonist||opioids||mu receptor||opioid side effects||biased agonism||partial agonism||zerumbone||chronic constriction injury (CCI)||allodynia||hyperalgesia||potassium channels||over-the-counter drugs||misuse||abuse||opioid drugs||pharmacology||codeine||dihydrocodeine||loperamide||opioid peptide||macrocyclic tetrapeptide||multifunctional ligands||kappa opioid receptor||analgesics||opioid liabilities||μ opioid receptor||receptor model||biased ligands||dependence||pain therapy||neonatal opioid withdrawal syndrome||naltrexone||6β-naltrexol||buprenorphine||G-protein bias||arrestin recruitment||respiration||mitragynine||heteromer||internalization||primary hippocampal culture||lysosomes||µ opioid receptor||molecular dynamics||docking||interaction fingerprints||biased agonists||SR-17018||PZM21||morphine||fentanyl||diphenethylamines||design and synthesis||structure–activity relationships||partial agonist||biased agonist||antagonist||binding affinity||selectivity||n/a